Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.

Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.

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BackgroundA role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but ngetikin studies on cervical adenocarcinoma are limited.MethodsA total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C.trachomatis and HPV DNA here by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.ResultsOnly 1.7% of samples were positive for C.

trachomatis, with no significant differences between AC/AIS cases and controls.HPV-positivity was detected in 49.3% of C.trachomatis-negative and 65.4% C.

trachomatis-positive samples, respectively.ConclusionsA large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C.trachomatis infection.ImpactC.trachomatis appears not to be involved in cervical adenocarcinomas.